Key result
Ticagrelor triggers rare hypersensitivity reaction causing drug-induced urticaria after acute myocardial infarction.
Why the study?
Hypersensitivity reaction to ticagrelor is rarely recognized despite its use as antiplatelet therapy in acute coronary syndrome patients.
Case Report (n=1)
Ticagrelor can rarely cause hypersensitivity reactions such as drug-induced urticaria, which resolves upon discontinuation and symptomatic treatment.
Ticagrelor hypersensitivity warrants clinical vigilance in ACS; this case leaves open true incidence and management strategies.
Ticagrelor is an antiplatelet therapy used for secondary prevention in patients with acute coronary syndrome. Adverse effects of ticagrelor are hemorrhage, headache, dyspnea, epistaxis, ventricular pauses or bradycardia, hyperuricemia and elevation of creatinine level. However, hypersensitivity reaction of ticagrelor is rarely recognized. We present a 63-year- old male patient diagnosed with acute myocardial infarction, ST-segment elevation and ectasia and low blood flow disease documented by coronary angiogram. He required dual antiplatelet therapy with acetylsalicylic acid (ASA) and ticagrelor, developing drug-induced urticaria according to dermatology consultation. He was treated with topical steroids, oral antihistamines and ticagrelor discontinuation. This case is considered a rare case of reaction to the antiplatelet agent described herein.
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Clavijo et al. (2020) conducted a case report in Acute myocardial infarction (n=1). Ticagrelor was evaluated on Drug-induced urticaria. Ticagrelor therapy in a 63-year-old male with acute myocardial infarction led to a rare hypersensitivity reaction manifesting as drug-induced urticaria.
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