Key result
Western diet induces obesity and steatosis but fails to alter cardiac metabolism or function.
Why the study?
The impact of obesity progression on cardiac metabolism and function over time was uncertain.
Does a high-fat and high-sucrose diet alter cardiac metabolism and function over time in male Wistar rats?
RCT
Randomly divided
Does a high-fat and high-sucrose diet alter cardiac metabolism and function over time in male Wistar rats?
In a rat model, diet-induced obesity progression caused hepatic steatosis and metabolic comorbidities but did not lead to early cardiac metabolic or functional decline.
Answers are grounded in this paper and cite their sources.
Obesity-driven adiposity in rats may signal evolving cardiac risk; leaves open any human metabolic cardiomyopathy link.
The goal of this study was to test if obesity progression can be a risk factor to alter cardiac metabolism and function along the time. Male Wistar rats were randomly divided to receive either chow diet (12.0% calories from fat) [C group] or high-fat diet (49.7% calories from fat) plus sucrose in the drinking water (100% from carbohydrate) [H group] for 6, 12 and 24 weeks. The Western diet significantly increased adiposity index of rats in all three experimental periods compared to C group. This was associated with increased plasma levels of insulin, resistin, leptin, glucose, triacylglycerol and decreased adiponectin, however, all variables were stable along the time except insulin and leptin. Plasma free fatty acid was only elevated with 24 weeks treatment. The obesity status resulted in hepatic steatosis progression in H group, while oxidative stress, hepatic inflammatory foci as well as TNF-α and IL-6 mRNA levels were not affected. There are no cardiac performance decline as well as metabolism cardiac changes in H group when compared with C. In conclusion, Western diet induced and promoted obesity, co-morbidities and hepatic steatosis progression while was not associated with apparent alterations of cardiac metabolism and function. These results suggest that obesity progression seems to affect the organs of distinct ways, and cardiac dysfunction is a question of time
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Nascimento et al. (2021) conducted an RCT in Obesity. Western diet (high-fat diet plus sucrose) vs. Chow diet (12.0% calories from fat) was evaluated on Cardiac metabolism and function. A Western diet (49.7% fat) induced obesity and hepatic steatosis in male Wistar rats over 24 weeks, but did not cause apparent alterations in cardiac metabolism and function.
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