Lewis acid-promoted cyclization of the N-tosylimine derived from aldehvde alkene (18) affords an interesting rearranged seven-membered ring tricvcle -~~~, (21) ;ather than the dxpected intermediatevcontaini& the lysergic acid skeleton.The Ergot alkaloids represent an important subgroup of indole alkaloids because of their wide range of biological activity.l.2Many Ergot alkaloids and their derivatives have been reported to produce such diverse effects as uterotonic action, increase or decrease in blood pressure, induction of hypothermia and emesis, and control of the secretion of pituitary hormones.These biological responses are primarily mediated by noradrenaline, serotonin, or dopamine receptors.
No takes yet. Share an insight, caveat, or question.
Weinreb et al. (1996) studied this question.