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September 29, 2018Expert Opinion on Drug DiscoveryOpen Access

Opportunities and challenges with animal models for acute radiation syndrome drug discovery

Vijay K. Singh Paola T. Santiago Thomas J. MacVittie

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Abstract

Radiation exposures from accidents or other sources of radiation can result in different types of radiation injuries, dictating the diagnostic and therapeutic measures. The clinical progression of ...

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Singh et al. (2018) studied this question.

synapsesocial.com/papers/6ab38672fbd5a92c08af58d0 https://doi.org/10.1080/17460441.2018.1526172

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Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

1Acute radiation syndrome caused by accidental radiation exposure - therapeutic principlesReview · 2011 · 174 citations
2Multi-organ involvement as a pathogenetic principle of the radiation syndromes: a study involving 110 case histories documented in SEARCH and classified as the bases of haematopoietic indicators of effectOriginal Research · 2005 · 111 citations
3Models for Evaluating Agents Intended for the Prophylaxis, Mitigation and Treatment of Radiation Injuries Report of an NCI Workshop, December 3–4, 2003Original Research · 2004 · 246 citations
4A review of radiation countermeasures focusing on injury-specific medicinals and regulatory approval status: part I. Radiation sub-syndromes, animal models and FDA-approved countermeasuresReview · 2017 · 175 citations
5Animal Models for Medical Countermeasures to Radiation ExposureOriginal Research · 2010 · 423 citations

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