Able antigen analogues: Analogues of the mycobacterial sulfoglycolipid antigen 1 isolated from Mycobacterium tuberculosis have been prepared by a short and general route. Some derivatives showed interesting immunogenic properties and activated cytotoxic T cells. Immunogenic analogues contained a chiral saturated or α,β-unsaturated polymethylated fatty acid with S configured stereogenic centers at the 3-position of the trehalose core.
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Guiard et al. (2008) studied this question.
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