Polymer–inorganic nanocomposite microspheres synthesized by a simple solid-in-oil-in-water emulsion technique can provide both sustained protein release with tunable gradient, and delayed protein release with tunable lag time. Microspheres with a tunable lag time between 2 and 6 weeks (see figure) can be used as delayed release vehicles for the sequential delivery of multiple proteins.
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Pitukmanorom et al. (2008) studied this question.
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