Key result
This review highlights the DEAH-RHA helicase•zinc finger cofactor system in kinetoplastid RNA editing and its potential functional parallels in nematode embryogenesis and human antivirus protection.
This review highlights the evolutionary conservation and functional parallels of DEAH-RHA helicase•zinc finger cofactor systems across highly divergent eukaryotic lineages.
No immediate clinical implications for antiviral strategies; leaves open functional validation of DEAH-RHA parallels in human systems.
Multi-zinc finger proteins are an emerging class of cofactors in DEAH-RHA RNA helicases across highly divergent eukaryotic lineages. DEAH-RHA helicase•zinc finger cofactor partnerships predate the split of kinetoplastid protozoa, which include several human pathogens, from other eukaryotic lineages 100-400 Ma. Despite a long evolutionary history, the prototypical DEAH-RHA domains remain highly conserved. This short review focuses on a recently identified DEAH-RHA helicase•zinc finger cofactor system in kinetoplastid RNA editing, and its potential functional parallels with analogous systems in embryogenesis control in nematodes and antivirus protection in humans.
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Cruz‐Reyes et al. (2016) reported a review. DEAH-RHA helicase•zinc finger cofactor system was evaluated. This review highlights the DEAH-RHA helicase•zinc finger cofactor system in kinetoplastid RNA editing and its potential functional parallels in nematode embryogenesis and human antivirus protection.
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