β-glucans are glucose homopolymers known to modulate immunity. Here, the β-glucan effect on sow antibody production and passive immunisation of neonatal pigs was analysed. Treatments included: (1) corn-soy fed Control group; (2) β-glucan; (3) Actinobacillus pleuropneumoniae (App) vaccination; and (4) β-glucan + App vaccination. Birth and weaning weights were not affected (P>0.05) by treatment. Independent of treatment, IgA, IgG and IgM in colostrum were elevated and declined rapidly. Vaccination against App resulted in an increase (P<0.05) in IgG and IgA specific for App serotypes 1, 5 and 7 in colostrum and milk, and a corresponding increase (P<0.05) in serum in pigs at 4 d of age. However, β-glucan did not enhance specific App antibodies in pig serum. While the dosage used here did not enhance passive immunisation in pigs, β-glucan can be potentially efficacious as an oral adjuvant to enhance immunoglobulin production in response to vaccination.
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Chau et al. (2009) studied this question.
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