ETS emerges to heat up adipose

This is the authors' abstract. We don't add key points for this paper.

, Xue and colleagues (doi:10.1101/gad.352748.125) identify ETV4 as a transcription factor binding a -12 kb enhancer of UCP1 to promote chromatin accessibility, histone acetylation, and gene expression. This role for ETV4 in thermogenesis expands its known functions in adipogenesis. Importantly, these findings also highlight an emerging, broader role for E26 transformation-specific (ETS) transcription factors in adipose biology.