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June 7, 2006The Anatomical Record Part A Discoveries in Molecular Cellular and Evolutionary BiologyOpen Access

Multiple roles for emerin: Implications for Emery‐Dreifuss muscular dystrophy

James M. Holaska Katherine L. Wilson

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Abstract

X-linked Emery-Dreifuss muscular dystrophy (X-EDMD) is inherited through mutations in EMD, which encodes a nuclear membrane protein named emerin. Emerin is expressed in most cells, but EDMD strikes specific tissues. This review summarizes growing evidence that emerin has roles in both tissue-specific gene regulation and the mechanical integrity of the nucleus and discusses how these roles might impact EDMD.

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Holaska et al. (2006) studied this question.

synapsesocial.com/papers/6ab393fdd80422953829d362 https://doi.org/10.1002/ar.a.20334

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Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

1The Emery-Dreifuss muscular dystrophy phenotype arises from aberrant targeting and binding of emerin at the inner nuclear membraneOriginal Research · 1999 · 178 citations
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