Answers are grounded in this paper and cite their sources.
The discovery, development and implementation of two chemical routes to ABT-869 is reported. Optimization of the first-generation heterocycle formation and Suzuki coupling is briefly described. Key features of the second-generation synthesis include the development of a safe hydrazine condensation by utilizing an inorganic base to increase the onset temperature of exothermic decomposition. The second-generation Suzuki reaction is discussed in detail, culminating in the use of an oxygen monitor as a PAT to maximize reproducibility on scale.
No takes yet. Share an insight, caveat, or question.
Kruger et al. (2009) studied this question.
Synapse has enriched 10 related papers. Consider them for comparative context: