Toxic Reactions Accompanying Second Courses of Sulfonamides in Patients Developing Toxic Reactions During a Previous Course

Article1 April 1946TOXIC REACTIONS ACCOMPANYING SECOND COURSES OF SULFONAMIDES IN PATIENTS DEVELOPING TOXIC REACTIONS DURING A PREVIOUS COURSEHARRY F. DOWLING, M.D., F.A.C.P., HAROLD L. HIRSH, M.D., MARK H. LEPPERHARRY F. DOWLING, M.D., F.A.C.P.Search for more papers by this author, HAROLD L. HIRSH, M.D.Search for more papers by this author, MARK H. LEPPERSearch for more papers by this authorAuthor, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-24-4-629 SectionsAboutPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail ExcerptThe sulfonamide drugs are so commonly administered at the present time that practically every person has received one of them on some occasion. Consequently, it is of importance to consider what will happen when these individuals receive sulfonamides a second time. Lyons and Balberor1reported that in patients who received a course of sulfathiazole without exhibiting any toxic effects "drug fever" was more likely to develop during a second course of sulfathiazole than in patients receiving an initial course of this drug. Two of us2have shown that this principle also holds for other sulfonamides, and, furthermore, that when patients...Bibliography1. LYONSBALBEROR RHH: Febrile reactions accompanying the readministration of sulfathiazole, Jr. Am. Med. Assoc., 1942, cxviii, 955-958. CrossrefGoogle Scholar2. DOWLINGLEPPER HFMH: "Drug fever" accompanying second courses of sulfathiazole, sulfadiazine and sulfapyridine, Am. Jr. Med. Sci., 1944, ccvii, 349-353. CrossrefGoogle Scholar3. PARK RG: Sulphonamide allergy, Brit. Med. Jr., 1944, i, 781-782. CrossrefGoogle Scholar This content is PDF only. To continue reading please click on the PDF icon. Author, Article, and Disclosure InformationAffiliations: *Received for publication August 2, 1945.From the George Washington Medical Division, Gallinger Municipal Hospital and the Department of Medicine, George Washington University.†Capt. Lepper's contribution to this study was made before he entered military service. PreviousarticleNextarticle Advertisement FiguresReferencesRelatedDetails Metrics Cited byDrug-Protein Conjugation and its Immunological ConsequencesImmunization of mice against barbiturates and the effect on the disposition of [3H]phenobarbitalThe SulfonamidesProlonged Treatment of Urinary-Tract Infections with SulfamethoxypyridazineCLINICAL TOXICITY OF SULFONAMIDESSulfonamideStatistical analysis of 242 cases of meningococcus meningitisDrug allergy 1 April 1946Volume 24, Issue 4Page: 629-633KeywordsArmed forcesDrugsFeversHospital medicineSulfonamide ePublished: 1 December 2008 Issue Published: 1 April 1946 PDF downloadLoading ...