Proof-of-principle imaging study demonstrates perivascular cerebrospinal fluid transport into brain tissue in humans, highlighting the existence of a human glymphatic pathway.
The glymphatic pathway was defined in rodents as a network of perivascular spaces (PVSs) that facilitates organized distribution of cerebrospinal fluid (CSF) into the brain parenchyma. To date, perivascular CSF and cerebral interstitial fluid exchange has not been shown in humans. Using intrathecal gadolinium contrast-enhanced MRI, we show that contrast-enhanced CSF moves through the PVS into the parenchyma, supporting the existence of a glymphatic pathway in humans.
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Yamamoto et al. (2024) studied this question.
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