Key result
Diabetes mellitus is linked to over a 6-fold higher rate of autonomic neuropathy.
Why the study?
Autonomic neuropathy is a disabling complication of diabetes mellitus, and its significant correlation with diabetes in a rural medical college setting was investigated.
Case-Control (n=100)
No
Autonomic neuropathy is highly prevalent among diabetic patients and is associated with prolonged QTc intervals and poorer glycemic control.
Autonomic neuropathy was associated with diabetes in this small rural cohort; leaves open broader applicability and need for prospective validation.
Exclusion Criteria1. Patients with severe anemia, congestive cardiac failure, renal failure, obstructive lung disease, liver diseases and A B S T R A C T Introduction:Diabetes Mellitus is a major health problem worldwide.Autonomic neuropathy is a disabling complication of Diabetes Mellitus.This study aims to detect cases of autonomic neuropathy and its significant correlation with Diabetes in a rural medical college. Material and methods:The study was carried out on 50 patients with diabetes mellitus, in the Department of Medicine, at MVJ Medical college and research Hospital, Hoskote over the period of 18 months (from June 2017 to November 2018).Results: Average age group of patients was 45-60 years.Impotence was the commonest symptom(35%) followed by postural giddiness (32%).Nearly 64% of cases had positive Autonomic scores.77% of cases with polyneuropathy had positive autonomic scores.Among the cases the mean HbA1C was 8.24±2.59% in those with positive Autonomic scores.46% cases had Prolonged Corrected QT-interval.Among them the corrected QT-interval was 6.46±0.79seconds.There is a significant decrease in number of tests being positive among those who take both insulin and Oral Hypoglycemics, as against those who take either one.Conclusions: There is an increased incidence of autonomic neuropathy among Diabetics.Proper treatment regimens and stricter lifestyle modifications help in controlling the glycemic status, which reduce the incidence of Autonomic dysfunction.
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Abhirami et al. (2020) conducted a case-control in Diabetes Mellitus (n=100). Diabetes Mellitus vs. Non-diabetic controls was evaluated on Positive autonomic score (>5.0) (p=<0.001). Diabetes mellitus was associated with a significantly higher prevalence of autonomic neuropathy compared to controls (64% vs 10%, p<0.001).
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