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High Resolution Image Download MS PowerPoint Slide A >7-year study was conducted using cynomolgus macaques ( Macaca fascicularis ) to evaluate the long-term effects of genetically modified (GM) maize on the immune status and serum metabolic profile across two generations. The GM insect-resistant and herbicide-tolerant maize line used carried the cry1Ab/cry2Aj and G10evo-EPSPS genes. The macaques were maintained on GM maize-based, non-GM maize-based, or normal diet for >7 years, and their offspring received the corresponding diet postweaning. Multigenerational analyses encompassed immunoglobulin profiles, cytokine networks, and serum metabolome characteristics to assess the potential impact of GM maize on immune system development and metabolic homeostasis. No statistically significant differences were observed in the majority of parameters between the GM-fed and control (non-GM and normal diet) groups. This longitudinal investigation provides substantial evidence for the metabolic equivalence and immunological compatibility of the GM maize formulation in cynomolgus macaques.
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Li et al. (2025) studied this question.
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