Association between the triglyceride-glucose index and cognitive function in stroke free patients with atrial fibrillation: A cross-sectional study

OBJECTIVES: No existing research has documented the correlation between the triglyceride-glucose (TyG) index and cognitive function in patients suffering from atrial fibrillation (AF). The objective of this study is to examine this potential association. METHODS: Patients diagnosed with AF were enrolled in this study from March 2021 to May 2022 at the cardiology department of West China Hospital, Sichuan University. TyG index was calculated. Cognitive function was evaluated using the Mini-Mental State Examination (MMSE) scale and Montreal Cognitive Assessment (MoCA), Verbal Fluency Test (VFT), Shape Trail Test (STT), Digit Symbol Substitution Test (DSST), and Stroop C scores and seconds. Logistic regression analyses were conducted to examine the association between the TyG index (continuous and quartiles) and cognitive function. RESULTS: A total of 142 patients were included. The median value of the TyG index was 1.28 (1.01, 1.71). After adjusted potential confounding factors, participants in the 4th quartile of the TyG index were not found to be associated with cognitive function (all P > 0.05). The findings for TyG as a continuous variable were consistent with these results. CONCLUSION: In patients with AF, the TyG index was found to be unrelated to low cognitive function as assessed by a comprehensive battery of tests. These findings should be validated in further studies.