Theoretical Connotation and Clinical Practice of Atopic Dermatitis Based on the Traditional Chinese Medicine Therapy of “Tranquilizing the Heart and Calming the Mind”

Atopic dermatitis (AD) is a chronic, relapsing inflammatory skin disease with a systemic pathogenesis that extends beyond the skin, significantly impacting patients’ psychological well-being and quality of life. The limited efficacy of conventional treatments for core psychosomatic issues such as chronic pruritus, sleep disturbances, and anxiety has spurred interest in complementary therapies such as traditional Chinese medicine (TCM). This study explores the theoretical basis, clinical application, and underlying mechanisms of the TCM approach known as “Tranquilizing the Heart and Calming the Mind” in managing AD. Based on canonical TCM literature such as the Huangdi Neijing, this article details the role of the “Heart” in AD, encompassing both its physiological functions and pathological contributions to disease development. These findings establish this method as central to the AD treatment approach, especially when managing prominent psychological and sleep-related symptoms. We propose a flexible clinical framework utilizing a modified formula pivoting on Os Draconis (Long Gu) and Concha Ostreae (Mu Li). This formula is intended to regulate the “Heart-Spirit” to alleviate internal wind and dryness, thereby breaking the vicious cycle of pruritus, calming agitation, improving sleep, and reducing recurrences. In summary, this TCM therapy offers both a robust theoretical framework and an effective, patient-centered strategy for comprehensive AD management, underscoring the critical connection between mental-emotional balance and skin health. Consequently, it is essential that future research focuses on high-level evidence and mechanistic insights to validate and translate this approach into global practice.