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Summary dsSwissKnife is an R package that enables several powerful analyses to be performed on federated datasets. The package works alongside DataSHIELD and extends its functionality. We have developed and implemented dsSwissKnife in a large IMI project on type 2 diabetes, RHAPSODY, where data from 10 observational cohorts have been harmonised and federated in CDISC SDTM format and made available for biomarker discovery. Availability and implementation dsSwissKnife is freely available online at https://github.com/sib-swiss/dsSwissKnife . The package is distributed under the GNU General Public License version 3. Contact mark.ibberson@sib.swiss
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Dragan et al. (2020) studied this question.