β-Cell Autoimmunity, Genetic Susceptibility, and Progression to Type 1 Diabetes in Unaffected Schoolchildren

Letters nondiabetic siblings of type 1 diabetic patients and therefore correlated with plasma concentrations of Lp(a) and fibrinogen.Cases of hyponatremia have been correlated with inflammation ( 14) and increased plasma interleukin Ϫ6 concentration (15).These findings are consistent with our hypothesis of an association among inflammatory markers, oxidative stress, and susceptibility to type 1 diabetes.Moreover, the familiarly overactive NHE could be viewed independently as further evidence for the presence in these families of a redox disequilibrium in which oxidation seems to be dominant.