Enantiomeric pairs of copper( ii ) complexes with tridentate Schiff bases derived from R - and S -methionine: the role of decorating organic groups of the ligand in crystal packing and biological activity

-methionine transporter, Mup1. A chemogenomic analysis of 3-S toxicity performed on a collection of yeast knockout mutants revealed that most of the deleted genes identified in the screen were involved in the cell response to oxidative stress, calcium-mediated response, or metal homeostasis. Altogether, it was concluded that 3-S accumulation may perturb the redox state of the cell, also interfering with the calcium-mediated response to oxidative stress or metal-related oxidative stress.