Key result
Acute IV GPIIb/IIIa inhibitors succeed with heparin, but chronic oral agents consistently fail.
Why the study?
Despite the documented benefits of various antiplatelet therapies, chronic oral GPIIb/IIIa antagonists failed in multiple cardiovascular settings, necessitating a review of their roles and future directions.
This review summarizes the established benefits of various antiplatelet therapies while highlighting the clinical failure of chronic oral GPIIb/IIIa antagonists.
Antiplatelet therapies remain foundational in thrombosis prevention; review leaves open optimal agent selection and durations in contemporary practice.
Cardiovascular and cerebrovascular diseases continue to be leading causes of death throughout the world. Blood platelets play a pivotal role not only in haemostasis but also in the pathogenesis of thrombosis and atherosclerosis, platelet aggregation being an essential step in the formation of either an effective haemostatic plug or an intravascular thrombus. The benefits of various antiplatelet therapies ranging from aspirin, ticlopidine, Clopidogrel, and intravenous platelet GPIIb / IIIa antagonists in various thromboembolic disorders are well documented. Despite of the success of intravenous acute GPIIb / IIIa blockade when given in conjunction with heparin, chronic oral GPIIb / IIIa antagonists with or without aspirin failed in various cardiovascular settings. This review highlights the role of the various antiplatelet therapies in thrombotic disorders as well as future directions.
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Shaker A. Mousa (2003) conducted a review in Thromboembolic and thrombotic disorders. Antiplatelet therapies (aspirin, ticlopidine, clopidogrel, GPIIb/IIIa antagonists) was evaluated. Intravenous acute GPIIb/IIIa blockade is successful when given with heparin, whereas chronic oral GPIIb/IIIa antagonists with or without aspirin have failed in various cardiovascular settings.
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