Inhibition of signal transduction pathways involved in inflammation

In order to target inflammatory processes effectively, it is necessary to understand, within an eukaryotic cell, how inflammatory reactions are generated and maintained.Therefore, this article will first concentrate on the signal transduction pathways and molecular mechanisms that drive inflammatory gene expression, followed by countering some of the published hypotheses that try to explain the inhibitory role of glucocorticoids.The current working model is included, which explains glucocorticoid action, and additionally points to an alternative or cooperative way of how to block inflammatory gene expression.