Prognostic evaluation of sex difference in adenosine deaminase and homocysteine activities of acute ischemic stroke patients

Aim of the present study was to investigate serial changes in adenosine deaminase (ADA) and total homocysteine (tHcy) activities in male and female acute ischemic stroke (AIS) patients to determine their prognostic value.ADA and tHcy activities were measured in follow-up blood sample collected from AIS patients at admission, 24 hrs, 48 hrs, 72 hrs, and 144 hrs after admission and in control subjects.We did not observe any significant difference in ADA and tHcy activities between male and female of AIS and control subjects.ADA activity was significantly high in male AIS patients as compare to female throughout the follow-up.There were no significant difference in tHcy activity between male and female of AIS patients.Similarly there were no significant differences in ADA and tHcy activities on comparing follow-up samples of AIS patients with that of admission value.In addition, m-RS scale in female was better than male AIS patients.Findings of this preliminary study suggest that increase in ADA activity in male AIS patient may reflect poor outcome than female.The tHcy activity is not related with the severity and out come after AIS.Further prospective studies are needed to see if ADA is clinically useful in outcome prediction after AIS.