Comparative assay evaluation demonstrates throughput limitations of standard ELISA in human serum samples, indicating clinical advantages for high-throughput multiplex platforms.
IntroductionInflammation is a protective response that is necessary for responding to invading pathogens.Cytokines, secreted by immune cells, play a major role in this response.Measurement and detection of cytokine levels in serum are essential in understanding biological homeostasis to maintain human health.Investigation of cytokines in serum analysis has been classically conducted by enzyme-linked immunosorbent assay (ELISA).With an increasing demand for rapid and precise measurements for multiple cytokines and other biomarkers, ELISA has been the standard for quantitative serum analysis.Yet, it is not well suited for high throughput multiple
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Corey T. Ungaro (2020) studied this question.
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