Key result
Cisplatin treatment linked to acute cerebrovascular accident in a patient taking concurrent letrozole.
Why the study?
Arterial thrombotic events after chemotherapy are less documented compared to venous thrombotic events in cancer patients.
Does cisplatin treatment cause acute cerebrovascular accidents in patients with cancer taking letrozole?
Case Report (n=1)
Does cisplatin treatment cause acute cerebrovascular accidents in patients with cancer taking letrozole?
Cisplatin chemotherapy may be associated with rare arterial thrombotic events such as acute cerebrovascular accidents.
Answers are grounded in this paper and cite their sources.
Case raises cisplatin cerebrovascular risk with letrozole; hypothesis-generating and should not change practice.
Vascular thrombotic events are common in patients with cancer and chemotherapy is considered a contributing factor. Venous thrombotic events are more common than arterial ones which are less documented. In this report, we describe a patient with right homonymous hemianopsia following treatment with cisplatin for small cell lung carcinoma while also taking letrozole. A brief review of the literature on arterial thrombotic events after chemotherapy follows.
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Digklia et al. (2012) conducted a case report in Small cell lung carcinoma (n=1). Cisplatin and letrozole was evaluated on Acute cerebrovascular accident (right homonymous hemianopsia). A patient developed an acute cerebrovascular accident presenting as right homonymous hemianopsia following treatment with cisplatin for small cell lung carcinoma while concurrently taking letrozole.
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