Key result
Immunoadsorption sharply lowers cardiac index and raises systemic vascular resistance in autoantibody-positive dilated cardiomyopathy.
Why the study?
Immunoadsorption has been shown to improve left ventricular function in DCM patients positive for beta1-adrenoceptor autoantibodies, but acute hemodynamic effects during treatment were not invasively measured.
Does immunoadsorption affect acute hemodynamics in patients with dilated cardiomyopathy positive for beta1-adrenoceptor autoantibodies?
Case Report (n=3)
Does immunoadsorption affect acute hemodynamics in patients with dilated cardiomyopathy positive for beta1-adrenoceptor autoantibodies?
Immunoadsorption in DCM patients positive for beta1-adrenoceptor autoantibodies causes substantial acute hemodynamic changes, including decreased cardiac index and increased systemic vascular resistance.
Answers are grounded in this paper and cite their sources.
May induce acute hemodynamic worsening in beta1-AAB-positive DCM; hypothesis-generating and requires prospective confirmation before any clinical consideration.
In two recent studies immunoadsorption improved left ventricular function in patients with dilated cardiomyopathy (DCM) who were positive for cardiostimulatory autoantibodies against the human beta 1-adrenoceptor (beta 1-AAB). In this study we invasively measured acute hemodynamics during immunoadsorption. Three patients with DCM, who were positive for beta 1-AAB (NYHA-class III, left ventricular ejection fraction < 0.3), were treated with 1 immunoadsorption session daily on 5 consecutive days. Immunoadsorption induced a strong decrease of cardiac index, whereas systemic vascular resistance increased. Baseline levels were reached again several hours after therapy ended. We conclude that during immunoadsorption substantial hemodynamic changes occur in patients positive for beta 1-AAB.
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Christ et al. (2001) conducted a case report in Dilated cardiomyopathy (DCM) positive for beta 1-AAB (n=3). Immunoadsorption was evaluated on Acute hemodynamics (cardiac index and systemic vascular resistance). Immunoadsorption induced a strong decrease of cardiac index and an increase in systemic vascular resistance in patients with dilated cardiomyopathy positive for beta 1-AAB.
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