Efficient synthesis of novel spiro-furo-pyrido-pyrimidine-indolines by manganese ferrite nanoparticles as a highly active magnetically reusable nanocatalyst in water

A one-pot and three-component reaction for the efficient, green and economical synthesis of novel spiro-furo-pyrido-pyrimidine-indolines using 2,6-diaminopyrimidine-4(3H)-one or uraciles, isatins and tetronic acid or anilinolactones in the presence of manganese ferrite nanoparticles as a magnetic catalyst in water is described. The present synthesis shows attractive characteristics such as; the use of magnetically recoverable and reusable catalyst, convenient one-pot operation, short reaction periods, good to high yields and the use of water as a green reaction medium and is considered to be relatively environmentally benign.