Key result
The A allele of the LOX rs1800449 polymorphism was associated with a significantly increased risk of ovarian cancer (OR 1.866; 95% CI 1.112-3.16; p=0.017).
Why the study?
Is LOX G473A polymorphism and serum LOX level associated with ovarian cancer risk in an Eastern Indian population?
Case-Control
Is LOX G473A polymorphism and serum LOX level associated with ovarian cancer risk in an Eastern Indian population?
The A allele of the LOX gene rs1800449 polymorphism and elevated serum LOX levels are associated with increased risk and advanced stage of ovarian cancer in an Eastern Indian population.
Answers are grounded in this paper and cite their sources.
AA genotype and higher serum LOX were associated with ovarian cancer risk; leaves open diagnostic or prognostic utility pending prospective validation.
(1) Background: Lysyl oxidase (LOX) plays a dual role in carcinogenesis and studies show a higher risk of cancer in LOX G473A variants. The present study evaluated the pattern of LOX G473A polymorphism (rs1800449) and serum LOX levels in ovarian cancer patients. (2) Methods: Serum LOX levels were estimated by enzyme linked immunosorbent assay (ELISA). A polymorphism of rs1800449 of LOX gene was detected by the polymerase chain reaction-restriction fragment length polymorphism (PCR-RFLP) method. Selected samples were sequenced for external validation. (3) Results: A majority of study participants were from low socio-economic status. Serum LOX level was significantly higher in ovarian cancer patients as compared to control. Serum LOX level in early-stage ovarian cancer was significantly lower as compared to advanced stage (FIGO stage III & IV). Wild type GG genotype was used as reference. Genotypes AA were associated with a significant risk of epithelial ovarian cancer (OR 3.208; p value- 0.033). A allele of rs1800449 polymorphism of LOX gene, the odds ratio was 1.866 (95% Confidence Interval 1.112–3.16) p value = 0.017 (4) Conclusions: A allele of rs1800449 polymorphism of LOX gene presents an increased risk of ovarian cancer in East Indian population. Serum LOX levels could be a potential biomarker for the diagnosis and prognosis of ovarian cancer.
No takes yet. Share an insight, caveat, or question.
Kumari et al. (2021) conducted a case-control in Ovarian cancer. LOX G473A polymorphism (rs1800449) A allele vs. Wild type GG genotype was evaluated on Risk of ovarian cancer (OR 1.866, 95% CI 1.112-3.16, p=0.017). The A allele of the LOX rs1800449 polymorphism was associated with a significantly increased risk of ovarian cancer (OR 1.866; 95% CI 1.112-3.16; p=0.017).
Synapse has enriched 10 related papers. Consider them for comparative context: