Sinogenic Intracranial Suppuration in Children: Systematic Review and Meta‐analysis

This is the authors' abstract. We don't add key points for this paper.

OBJECTIVE: To evaluate temporal trends in the management of sinogenic intracranial suppuration and its outcomes in children. DATA SOURCES: A systematic search of databases was performed (Medline, Embase, Cochrane, ClinicalTrials.gov). REVIEW METHODS: Studies in children (age <18 years) with sinogenic subdural empyema, extradural abscess, and intraparenchymal abscess were included. Data on treatment strategies were extracted. Primary outcome was death <90 days. Secondary outcomes were return to theater, neurologic disability at 6 months, and length of stay. Random effects meta-analysis and meta-regression were performed to investigate the effect of time and endoscopic sinus surgery (ESS) on these outcomes. ESS was not associated with improved mortality, reduced need for revision surgery, or neurologic disability. CONCLUSION: The outcomes of sinogenic intracranial complications have not changed over the last 45 years, and ESS was not associated with improved patient outcomes. Further high-quality studies are required to determine the most appropriate treatment modalities to improve the burden of morbidity associated with sinogenic intracranial suppuration in children.