Key result
High-dose methotrexate treatment resulted in an 8.5% incidence of chemical pleuritis, presenting as sudden severe chest pain and pleural thickening after the third or fourth treatment.
Why the study?
Does high-dose methotrexate treatment cause chemical pleuritis presenting as acute chest pain?
Observational (n=210)
Does high-dose methotrexate treatment cause chemical pleuritis presenting as acute chest pain?
High-dose methotrexate can cause a benign, transient chemical pleuritis presenting as acute chest pain, which should be recognized to avoid unnecessary extensive clinical examinations.
No takes yet. Share an insight, caveat, or question.
Alerts clinicians to possible chemical pleuritis with high-dose methotrexate; hypothesis-generating and should not yet change practice.
Urban et al. (1983) conducted an observational in Patients receiving high-dose methotrexate (n=210). High-dose methotrexate (HDMTX) was evaluated on Incidence of chemical pleuritis. High-dose methotrexate treatment resulted in an 8.5% incidence of chemical pleuritis, presenting as sudden severe chest pain and pleural thickening after the third or fourth treatment.
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