Key result
BCNU therapy is linked to fatal interstitial pulmonary fibrosis.
Why the study?
There is convincing evidence that BCNU therapy can cause fatal interstitial pulmonary fibrosis, but detailed clinical and pathological descriptions are limited.
Does BCNU therapy cause interstitial pulmonary fibrosis?
Does BCNU therapy cause interstitial pulmonary fibrosis?
BCNU adjuvant therapy is associated with the development of fatal interstitial pulmonary fibrosis.
Answers are grounded in this paper and cite their sources.
Raises caution for fatal BCNU pulmonary fibrosis; confirms association in Level 5 evidence but leaves incidence open.
A case of interstitial pulmonary fibrosis following BCNU adjuvant therapy in a 49-year old man is reported. The diagnosis was suggested by clinical and post-mortem pathological findings. From our and other experiences, there is some convincing evidence that use of BCNU can cause fatal interstitial pulmonary fibrosis.
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Bardella et al. (1981) studied this question. BCNU therapy can cause fatal interstitial pulmonary fibrosis, as evidenced by clinical and post-mortem pathological findings.
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