Key result
A visceral to subcutaneous fat area ratio of 1.165 or higher was independently associated with a significantly increased risk of erosive esophagitis (OR 2.04).
Why the study?
Does a high abdominal visceral to subcutaneous adipose tissue ratio predict an increased risk of erosive esophagitis in adults aged >40 years?
Cross-Sectional (n=728)
No
Does a high abdominal visceral to subcutaneous adipose tissue ratio predict an increased risk of erosive esophagitis in adults aged >40 years?
Odds Ratio: 2.04 (95% CI 1.18–3.51)
p-value: p=0.010
A higher ratio of visceral to subcutaneous abdominal fat is significantly associated with an increased risk and severity of erosive esophagitis.
Higher VFA/SFA ratio was associated with EE; hypothesis-generating and requires prospective validation before any clinical use.
BACKGROUND: To investigate the association between abdominal fat distribution represented by the visceral fat area (VFA) to subcutaneous fat area (SFA) ratio, and erosive esophagitis (EE). METHODS: Seven hundred and twenty-eight participants aged >40 years underwent physical examination, blood tests, esophagogastroduodenoscopy, and abdominal computer tomography at Chung-Ang University Hospital from 2007 to 2012. RESULTS: Of 728 subjects, 65 (8.9%) had EE. The EE patients had higher body mass index, metabolic syndrome prevalence, triglyceride levels, and blood pressure (P < 0.05). The mean VFA/SFA ratio was higher in the EE group than in the non-EE group (1.30 vs. 0.92, P < 0.001). The predominance of EE in the group with higher VFA/SFA ratio was higher than in the group with lower VFA/SFA ratio (P < 0.001). A VFA/SFA ratio ≥1.165 had good accuracy to predict EE (area under the receiver-operating characteristic curve, 0.643). The VFA/SFA ratio and visceral fat volume were positively correlated with the severity of EE (P = 0.002), and a VFA/SFA ratio ≥1.165 was strongly correlated with the severity of EE (P < 0.001). CONCLUSION: The high VFA/SFA ratio can be a useful clinical predictor of EE.
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Ze et al. (2017) conducted a cross-sectional in Erosive esophagitis (n=728). High visceral to subcutaneous fat area (VFA/SFA) ratio (≥1.165) vs. Low VFA/SFA ratio (<1.165) was evaluated on Incidence of erosive esophagitis (OR 2.04, 95% CI 1.18-3.51, p=0.010). A visceral to subcutaneous fat area ratio of 1.165 or higher was independently associated with a significantly increased risk of erosive esophagitis (OR 2.04).
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