Hydrogen Bonding 12. A New QSAR for Upper Respiratory Tract Irritation by Airborne Chemicals in Mice

Upper respiratory tract irritation of male Swiss OF1 mice by airborne chemicals is well correlated by the following equations for the toxicity of nonreactive compounds, magnified image FRD′50 is the concentration in mol 1−1 of the airborne chemical required to elicit a 50% decrease in respiratory rate, and the explanatory variables are δ2 a polarisability correction term, π the solute dipolarity, α the solute hydrogen‐bond acidity, Vx the characteristic volume, and L16 the gas/hexadecane partition coefficient. These equations considerably resemble corresponding equations for gas/liquid partition coefficients into organic bases such as tricresylphosphate, but do not resemble an equation for gas/water partition coefficients.