Key result
This review describes recent advances in the molecular mechanisms of calcium-dependent platelet activation and identifies potential targets for pharmacological interventions in disease states.
This review highlights the molecular mechanisms of calcium signaling in platelet activation and identifies potential novel pharmacological targets for thrombosis.
No immediate practice change; leaves open whether identified calcium targets yield effective antithrombotic therapies.
Platelets are involved in haemostasis and vessel integrity under physiologic conditions, and in thrombosis under disease states. Platelet activation upon stimulation with various agonists in vitro and in vivo, is strongly dependent on an increase of intracellular Ca(2+) concentration. The latter results from Ca(2+) release by the dense tubular system (DTS), and Ca(2+) entry from the extracellular space. Recent advances in identification of the molecular mechanisms involved in these processes are described in this review, along with potential targets for pharmacologic interventions in disease states.
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Davlouros et al. (2016) conducted a review in Platelet activation and thrombosis. This review describes recent advances in the molecular mechanisms of calcium-dependent platelet activation and identifies potential targets for pharmacological interventions in disease states.
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