Key result
Single 50-mg hydrochlorothiazide dose triggers rapid idiosyncratic pulmonary edema.
Why the study?
Pulmonary edema occurring shortly after ingestion of hydrochlorothiazide in patients without heart disease was not previously characterized.
Case Report (n=2)
Hydrochlorothiazide can cause acute pulmonary edema as a rare idiosyncratic reaction.
HCTZ may trigger acute noncardiogenic pulmonary edema; leaves open incidence, mechanisms, and risk factors.
Pulmonary edema developed in two women (44 and 65 years of age) within 45 minutes after they had ingested single 50-mg tablets of hydrochlorothiazide. There was no history of heart disease, and the drug was taken for weight reduction in one patient and for mild hypertension in the other. On admission to the hospital, x-ray films of the chest showed congestive changes in the lungs. The arm-to-tongue circulation time was normal. Clinical and laboratory data did not support a diagnosis of myocardial infarction or pulmonary embolus. It is postulated that these were idiosyncratic reactions to the drug.
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A D Steinberg (1968) conducted a case report in Pulmonary edema (n=2). Hydrochlorothiazide was evaluated on Pulmonary edema. Ingestion of a single 50-mg tablet of hydrochlorothiazide resulted in the rapid development of pulmonary edema in two women, postulated to be an idiosyncratic reaction.
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