Objective: To evaluate and compare the dissolution effectiveness of three organic solvents-xylene, tetrachloroethylene, and refined orange oil-on four root canal sealers: AH Plus, AVUE A+, Endoseal, and Bio-C.Methodology: The solubility of AH Plus (Dentsply Sirona), Avue A+ (Calcium Hydroxide Based Root Canal Sealer, Dental Avenue India Pvt. Ltd. ss), Endoseal (Zinc Oxide Eugenol Based Root Canal Sealer, Prevest Denpro), Bio-C Sealer (Angelus Bio-C Sealer, Bioceramic Root Canal Sealer) was assessed in xylene (Merck PVT LTD), tetrachloroethylene (Qualikems PVT LTD), refined orange oil, and distilled water.A total of forty-eight samples of root canal sealers were prepared and divided into four equal groups, each corresponding to one of the selected solvents.Several commercially available root canal sealers exhibit unique physicochemical properties.The selected samples (n = 12) were immersed separately in each solvent for 10 minutes at room temperature.The means of weight loss were determined for each material in each solvent pre-and post-immersion.Data were analyzed using one-way ANOVA and Tukey post-hoc test.Results: Bio-C Sealer exhibited significantly distinct solubility across all tested solvents.It differed from all other sealers in Xylene and Orange Oil.In Tetrachloroethylene, Bio-C, Avue A+, and ZnOE varied significantly, while AH Plus did not.Conclusion: Dissolution efficacy is both sealer and solvent-specific: Xylene works best on epoxy-resin-based sealers, while tetrachloroethylene is superior for calcium-silicate-based sealers.Refined orange oil, a biocompatible alternative, showed intermediate effectiveness.
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Balachandran et al. (2026) studied this question.
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