Self-destruction: Attachment of a photoreactive RuII complex to a guanine-containing oligonucleotide has led to an innovative biomolecular tool for gene silencing studies. This conjugate can be selectively photo-cross-linked with its complementary strand but undergoes a self-inhibition (or “seppuku”) process in the presence of a noncomplementary target (see picture), which is an attractive strategy to avoid undesired secondary photoeffects.
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Gac et al. (2008) studied this question.
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