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A facile and efficient synthetic method for the construction of C3-hydroxyalkylated imidazo[1,2- a ]pyridines and indoles by a Zn(OTf) 2 -catalyzed Friedel–Crafts hydroxyalkylation of imidazo[1,2- a ]pyridines and indoles with carbonyl compounds under mechanochemical conditions is reported. Good product selectivity, shorter reaction time, ambient reaction temperature, tolerance of a wide range of functional groups, broad substrate scope, moderate to good yield of products, and scalability are the salient features of the developed methodology.
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Meena et al. (2023) studied this question.
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