Experimental study demonstrates continuous-flow dissolution under sink conditions using clomipramine, indicating a reliable automated method for solid dosage testing.
An automated apparatus for dissolution rate studies of solid dosage forms under sink conditions at constant volume has been developed. Sink condition was maintained in the small volume of the buffer by continuous elimination of the solution and replacement with fresh buffer. A mathematical treatment of the dissolution-dilution system for the apparatus is given. The validity of the calculations has been proved using clomipramine solution and tablets.
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Richter et al. (1969) studied this question.
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