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Neurofibromatosis type 1 (NF1; OMIM 162200) is one of the most common neurogenetic conditions, affecting 1 in 3,000 people worldwide. Characterized by a propensity to develop nervous system tumors, learning and behavioral deficits, and pigmentary abnormalities, NF1 is caused by a germline sequence alteration in the NF1 gene (OMIM: 613113; chromosome 17q11.2). In addition, somatic NF1 sequence changes have been reported in numerous other cancers,1 extending their importance to malignancies occurring in the general population.
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Anastasaki et al. (2017) studied this question.
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