Evaluating the Effect of Scaling and Root Planing on the Salivary Levels of IL6 and RANKL

Periodontitis is a chronic inflammatory disease affecting the teeth'supporting structures. Scaling and root planing (SRP) is a foundational non-surgical periodontal therapy that aims to disruptthe subgingival biofilm and facilitate the healing of the periodontal tissues. The influence of SRP on salivary levels of inflammatory biomarkers, such as interleukin-6 (IL-6) and receptor activator of nuclear factor kappa-Β ligand (RANKL), isnot fully understood.Purpose: The purpose of this study is to evaluate the effect of non-surgical periodontal treatment (scaling and root planing) on the salivary levels of IL-6 and RANKLMethods: This clinical trial study, conducted with meticulous attention to detail, included 30 participants with periodontitis.Clinical parameters (plaque index (PI), bleeding on probing (BOP), probing pocket depth (PPD), and clinical attachment level (CAL)) were examined at the baseline visit, after seven days, and after 30 days of non-surgical periodontal treatment. The salivary levels of interleukin-6 (IL-6) and receptor activator of nuclear factor kappa-Β ligand (RANKL) were measured and compared before and after treatment, ensuring a comprehensiveunderstanding of the subject.Results: All clinical periodontal parameters were reduced (PI,BOP, PPD, and CAL) with a significant difference between baseline and the second visit scores (p= <0.0001). The salivary concentration of IL-6 and RANKL was decreased in all patients,with a significant difference between the baseline and the second visit measurement (p= <0.0001).Conclusions: Scaling and root planing significantly affect the treatment of periodontitis by improving periodontal parameters and reducing salivary IL-6 and RANKL concentrations.