Mechanomedicine in 2025: From Mechanical Insight to Clinical Translation

Mechanical cues are increasingly recognized as important determinants of tissue function, disease progression, and therapeutic response, making mechanomedicine an important area of biomedical research and clinical translation. This review summarizes major advances in mechanomedicine reported in 2025, when mechanical cues were measured with greater precision, their biological significance was interpreted more deeply, and these insights were translated more effectively into clinically relevant diagnostics and therapeutics. We first discuss biomechanics and mechanobiology, focusing on advances in multiscale mechanical measurement, modeling, and the biological interpretation of mechanical cues. We then examine progress in mechanodiagnostics and mechanotherapeutics, highlighting developments in sensing platforms, wearable and implantable systems, biomaterials, ultrasound-based interventions, and therapies targeting mechanotransduction pathways. Across these areas, artificial intelligence is used not as a separate theme, but to improve data integration, analysis, and interpretation in support of clinical translation. Finally, we outline the main requirements for clinical translation, including standardized mechanical biomarkers, standardized data frameworks, interpretable models, and rigorous prospective validation.