Efficient Suzuki-Miyaura Coupling of Deactivated Aryl Chlorides Catalyzed by an Oxime Palladacycle

Aryl chlorides are efficiently cross-coupled with aryl boronic acids using 0.25 mol% of 4,4′-dichlorobenzophenone oxime derived palladacycle as precatalyst in the presence of 1 mol% of [HP(t-Bu)3]BF4 as ligand, K2CO3 as base, TBAOH as additive, and DMF as solvent under conventional thermal or MW irradiation conditions. Under these simple reaction conditions a wide array of deactivated and hindered aryl chlorides react cleanly to afford in high yields functionalized biaryl derivatives.