Use of Bromelain for Mild Ulcerative Colitis

Letters18 April 2000Use of Bromelain for Mild Ulcerative ColitisSunanda Kane, MD, MSPH and Michael J. Goldberg, MDSunanda Kane, MD, MSPHUniversity of Chicago Hospitals; Chicago, IL 60637 (Kane)University of Chicago Hospitals; Chicago, IL 60637 (Goldberg) and Michael J. Goldberg, MDUniversity of Chicago Hospitals; Chicago, IL 60637 (Kane)University of Chicago Hospitals; Chicago, IL 60637 (Goldberg)Author, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-132-8-200004180-00026 SectionsAboutFull TextPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail TO THE EDITOR:Ulcerative colitis is a chronic condition characterized by inflammation of the mucosal layer of the colon. Despite multiple treatments, some patients continue to be symptomatic and seek alternative therapy. We describe two patients who achieved clinical and endoscopic remission after initiation of bromelain supplementation.A 67-year-old woman with a history of ulcerative proctitis continued to have three to four bloody bowel movements per day despite adequate doses of sulfasalazine, mesalamine, and topical steroids. She discovered bromelain at a nutrition/herbal store after researching "digestive aids" and anti-inflammatory drugs. Within a week of taking two tablets of bromelain at ...References1. Smyth RD, Moss JN, Brennan R, Harris JC, Martin GJ. Biochemical studies on the resolution of experimental inflammations in animals treated with bromelain. Exp Med Surg. 1967;25:229-35. MedlineGoogle Scholar2. Lotti T, Mirone V, Imbimbo C, Corrado F, Corrado G, Garofalo F, et al . Controlled clinical studies of nimesulide in the treatment of urogenital inflammation. Drugs. 1993;46 Suppl 1 144-6. CrossrefMedlineGoogle Scholar3. Chandler DS, Mynott TL. Bromelain protects piglets from diarrhea caused by oral challenge with K88 positive enterotoxigenic Escherichia coli . Gut. 1998;43:196-202. CrossrefMedlineGoogle Scholar4. Folwaczny C, Wiebecke B, Loeschke K. Unfractionated heparin in the therapy of patients with highly active inflammatory bowel disease. Am J Gastroenterol. 1999;94:1551-5. CrossrefMedlineGoogle Scholar5. Evans RC, Wong VS, Morris AI, Rhodes JM. Treatment of corticosteroid dependent ulcerative colitis with heparin—a report of 16 cases. Aliment Pharmacol Ther. 1997;11:1037-40. CrossrefMedlineGoogle Scholar Author, Article, and Disclosure InformationAffiliations: University of Chicago Hospitals; Chicago, IL 60637 (Kane)University of Chicago Hospitals; Chicago, IL 60637 (Goldberg) PreviousarticleNextarticle Advertisement FiguresReferencesRelatedDetails Metrics Cited byBromelain, a Group of Pineapple Proteolytic Complex Enzymes (Ananas comosus) and Their Possible Therapeutic and Clinical Effects. 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