Key result
TAGLN protein expression was significantly higher in lung adenocarcinoma tissues (68%) compared to adjacent tumor-free tissues (40%) and correlated with advanced tumor stage and lymph node metastasis.
Why the study?
Does TAGLN overexpression promote cell migration and correlate with tumor progression in lung adenocarcinoma?
Observational (n=75)
Does TAGLN overexpression promote cell migration and correlate with tumor progression in lung adenocarcinoma?
Absolute Event Rate: 68% vs 40%
p-value: p=0.001
TAGLN is upregulated under hypoxia in lung adenocarcinoma and promotes cell migration, suggesting it may serve as a therapeutic target and prognostic biomarker.
Authors
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TAGLN may promote hypoxia-driven tumor cell migration; hypothesis-generating for metastasis targets, requiring validation before clinical consideration.
Wu et al. (2014) conducted an observational in Lung adenocarcinoma (n=75). Lung adenocarcinoma (Tumor tissue) vs. Adjacent tumor-free tissue was evaluated on High TAGLN protein expression rate (score ≥4) (p=0.001). TAGLN protein expression was significantly higher in lung adenocarcinoma tissues (68%) compared to adjacent tumor-free tissues (40%) and correlated with advanced tumor stage and lymph node metastasis.
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