Outcome of Assisted Reproductive Technology

The birth in 1978 of Louise Brown, the first child conceived by in vitro fertilization, may be considered a milestone in the alleviation of long-standing infertility for many couples, especially those with female-factor infertility. But it became clear after about 10 years of experience that conventional in vitro fertilization was unable to help couples with severe male-factor infertility. Subsequently, direct injection of a single spermatozoon into the cytoplasm of an oocyte in vitro became feasible, and the first child conceived in this way was born in 1992.1 Intracytoplasmic sperm injection can be used successfully for men with severe oligospermia, and . . .