The pituitaries of adult female rats, under normal estrogen influence, stimulated moderate luteinization in normal and hypophysectomized recipient immature female rats. The pituitaries of adult female rats freed of estrogen stimulation through oophorectomy, invariably caused extensive luteinization of the recipient ovaries. This indicated that liberation of the hypophyseal luteinizing factor was minimal in the absence of estrogen; the factor remaining stored within the pituitary gland.
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Hellbaum et al. (1946) studied this question.