A Brucella suis mgtC mutant is defective for growth within macrophages and in low-Mg(2+) medium. These phenotypes are strikingly similar to those observed with mgtC mutants from Salmonella enterica and Mycobacterium tuberculosis, two other pathogens that proliferate within phagosomes. MgtC appears as a remarkable virulence factor that would have been acquired by distantly related intracellular pathogens to contribute to the adaptation to a low-Mg(2+) environment in the phagosome.
No takes yet. Share an insight, caveat, or question.
Lavigne et al. (2005) studied this question.
Synapse has enriched 3 closely related papers on similar clinical questions. Consider them for comparative context: