Harnessing hydrazoic acid in flow! 2-Oxazolines can be ring-opened in a very efficient manner by treatment with in situ generated hydrazoic acid. Despite the toxic and explosive nature of hydrazoic acid, this process can be conducted safely in a continuous-flow format with residence times as short as 5 min at 130 °C (see scheme).
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Gutmann et al. (2011) studied this question.
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