Answers are grounded in this paper and cite their sources.
The multi-component Ugi reaction has been employed to assemble a small library of affinity-based probes (AfBPs) that target potential protein tyrosine phosphatases. The probes showed good labelling of PTP1B and MptpB, and were subsequently used to label endogenous PTP1B in MCF-7 cell lysates.
No takes yet. Share an insight, caveat, or question.
Ge et al. (2012) studied this question.
Synapse has enriched 10 related papers. Consider them for comparative context: